Deus Ex: Mankind Divided
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KB Article: 75374
KB Category: [Technical Support]
KB Sub-category: [Crash / Freeze]

[PC] The game doesn't launch/crashes on boot.

If the game doesn't boot or crashes when trying to launch it, try the following:

1- Ensure that your system meets the system requirements.

2- Verify integrity of game cache. Open the title’s Properties and navigate to the Local Files tab. Click on the Verify Integrity of Game Cache. The process might take several minutes depending on the speed of the system’s HDD. This feature scans every file from the local game folder and double checks if anything is missing. Missing files will be downloaded and installed.

3- Reinstall the game by deleting Local Content and installing the game again.

4- Update your drivers (Framework, PhysX, DX runtime, GPU drivers)
     AMD: http://support.amd.com/en-us/download
     Nvidia: http://www.nvidia.com/Download/index.aspx
     Framework : https://www.microsoft.com/en-us/download/details.aspx?id=48130
     PhysX: http://www.nvidia.com/object/physx-9.16.0318-driver.html
     DX runtime: https://www.microsoft.com/en-us/download/details.aspx?displaylang=en&id=35

Note:
Avoid installing Nvidia’s GeForce Experience or AMD’s Raptr applications unless required to do so. These often try to “tweak” your game and feature overlays that might not bode well with the tested title. Select the “custom” option when installing drivers and uncheck the aforementioned software.